Like writing any code, building PyQt5 applications is all about approaching it in the right way. In the first part of the course we cover the fundamentals necessary to get you building Python GUIs as quickly as possible. By the end of the first part you'll have a running QApplication which we can then customize.
Getting started with PyQt5
Take your first steps building apps with Python & Qt5
Start with “Creating your first app with PyQt5”